formulation, characterization and optimization of liposomes containing eicosapentaenoic and docosahexaenoic acids; a methodology approach

Authors

zahra hadian shaheed beheshti university of medical sciences

mohammad ali sahari tarbiat modares university

hamid reza moghimi department of pharmaceutics, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran.

mohsen barzegar department of food science and technology, faculty of agriculture, tarbiat modares university, tehran, iran.

abstract

omega-3 fatty acids (fas) have been shown to prevent cardiovascular disease. the most commonly used omega-3 fatty acids like eicosapentaenoic acid (epa) and docosahexaenoic acid (dha) are highly vulnerable to oxidation and therefore, have short shelf life. recent advances in nanoliposomes provided a biocompatible system for stabilizing omega-3 fas. several methods could be implemented to prepare nanoliposomes. to the best of our knowledge, the performances of these methods in preparation omega-3 fas have not been examined. nanoliposomes were prepared by thin film hydration followed by one of the following methods: 1- extrusion, ultrasonic irradiation; 2- bath sonication; 3- probe sonication; or 4- combined probe and bath sonication. the size of liposomes obtained from methods 1 to 4 were 99.7 ± 3.5, 381.2 ± 7.8, 90.1 ± 2.3, and 87.1± 4.10 nm with ξ potential being -42.4 ± 1.7, -36.3 ± 1.6, -43.8 ± 2.4, and 31.6 ± 1.9 mv, respectively. the encapsulation efficiency (ee) for dha was 13.2 ± 1.1%, 26.7 ± 1.9%, 56.9 ± 5.2%, and 51.8 ± 3.8% for methods 1 to 4, respectively. the corresponding levels for epa were 6.5 ± 1.3%, 18.1 ± 2.3%, 38.6 ± 1.8%, and 38 ± 3.7%, respectively. the ee for dha and epa of liposomes for both methods 3 and 4 increased significantly (p < 0.05). propanal, as the major volatile product formed during liposomal preparations, amounts from 81.2 ± 4.1 to 118.8 ± 2.3 µgg-1.

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Journal title:

iranian journal of pharmaceutical research

جلد ۱۳، شماره ۲، صفحات ۳۹۳-۴۰۴

Keywords

formulation characterization liposome dha epa

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